Keloid Research Program

Keloids are benign skin tumors that result from a dysregulated wound-healing process in genetically predisposed patients. Despite their benign nature, keloids constitute a severe aesthetic and, in some cases, functional problems with important repercussions on patients' quality of life. Treatment of keloid is an area of unmet medical need. There are no wholly satisfactory treatments for his disease.

Keloid disorder has not attracted the attention of research community. Unfortunately, due to the social stigma of Keloid and the economical status of the population that is involved in Untied States, mostly African American, this disease has not received the attention that breast cancer or other conditions have received.

I am quite passionate about keloid research. It is only with good laboratory and clinical research that we can find better treatments for keloid. This disease has not captured the interest of research community; as such we have very limited knowledge about it.

My approach to this disease is a broad and comprehensive, spanning from basic science and laboratory work to therapeutic trials, from epidemiological studies to psychological assessment and research of the impact of the disease on patients. Below is list of my current research interests:

1-Genomics research to identify the key driving genes that are involved in pathogenesis of this disease.

2-Research in proteomics, signal transduction pathways and ligands to find druggable targets and innovative treatments.

3-Research in pathogenesis of keloid as it pertains to certain known conditions that trigger development of keloid. This study is in part supported by Rockefeller University's Center for Clinical and Translational Sciences; RUCCTS Grant # 2UL1RR024143 from the National Center for Research Resources, National Institutes of Health.

4-Establishment of a Keloid Tissue Bank which will allow ample access to keloid tissue for laboratory research.

5-Therapeutic Research of investigating the efficacy and of marketed drugs that can have an impact on the pathogenesis of keloid.

6-Epidemiological Research to study the natural history and clinical behavior of this disease as well as true incidence and prevalence of keloid disorder among various ethnic groups.

Trial 11-01: Web Based Investigation of Natural History of Keloid; An Online Survey of Patients with Keloid. The aim of this trial is to conduct a "10,000 patients" survey on the natural history of their keloids, and to explore patterns of clinical presentation, response to treatment and correlation with the ethnic background. This trial will provide valuable information about the prevalence of different keloid phenotypes.

Click HERE for the link to this study's website

Click HERE for the link to this study's listing on ClinicalTrials.gov website

Trial 11-04: Epidemiology Study of Keloid. Aim of this study is to determine the true epidemiology of keloid in general population. This will be a web based as well as paper questionnaire that is intended for mass distribution and collection of data. Sample size of this trial is (minimum of) 100,000. This will be a global trial.

Click HERE for the link to this study's website

Trial 11-07: Keloid Radiation Registry. Aim of this trial is to establish safety and efficacy radiation therapy in treatment of keloid. Radiation therapy has serious long term side effects, including causation of cancer, etc. This study aims to clarify the role of radiation therapy in keloid disorder.

Click HERE for the link to this study's website

Click HERE for the link to this study's listing on ClinicalTrials.gov website